Active metabolite sodium picosulphate binds to receptors on the intestinal wall, blocking the absorption of water and electrolytes and increases their secretion into the primobolan depot cycle intestinal lumen, resulting in enhanced peristalsis promoting accelerated intestinal contents. Laxative effect occurs within 10-12 hours after ingestion. Sodium picosulphate as the hydrophilic primobolan depot cycle substance is practically not absorbed through the lipophilic membrane of intestinal cells. Therefore, after the ingestion of sodium picosulphate relatively quickly passes through the stomach and small intestine intact. Approximately 70% of the dose primobolan depot cycle enters the colon after 3 hours after administration. In the large intestine by hydrolysis under the influence of sodium picosulfate intestinal microorganisms lipophilic active metabolite formed, which easily penetrates through biological cell membranes, stimulating neuroreceptors colonic mucosa membranes.
Hypersensitivity to sodium picosulphate, triarilmetanu, parabens and other ingredients, intestinal obstruction, incarcerated hernia, appendicitis, peritonitis, acute inflammatory diseases of the abdominal cavity, including pancreatitis and acute enterocolitis, intestinal and uterine bleeding, abdominal pain, unexplained genesis, nausea, vomiting of unknown origin, cystitis, severe dehydration, spastic constipation, a condition after operations on the abdominal organs, I trimester pregnancy, breastfeeding, children younger than 4 years.
Children older than 4 years.
Pregnancy and lactation
In II and III trimester of pregnancy, the primobolan depot cycle drug can be taken only in cases where the potential benefits of therapy for the mother is much higher than the potential risk to the fetus.
Dosing and Administration
Inside, diluted in a little water before bedtime. Adults and children over 10 years : 12-24 drops by (5-10 mg). Children from 4 years to 10 years: 6-12 drops (2, 5-5 mg). depending on the effect of the dose in subsequent receptions increases or decreases.
Overdose Symptoms: cm. See “Side effects”, as well as paroxysmal abdominal pain, ischemia of the colon mucosa, hyperaldosteronism, urolithiasis, renal tubular damage. Treatment: gastric lavage, correction of fluid and electrolyte balance, antispasmodics.
As a rule, short-term use of sodium primobolan depot cycle picosulphate has almost no side effects. Side effects develop during long-term treatment. From the digestive system: the aggravation of constipation, megacolon. At higher doses – colic, diarrhea, intestinal spasms. On the part of metabolism: a violation of water-electrolyte balance, dehydration, hyponatremia. Cardio-vascular system: decrease in blood pressure. From the nervous system: convulsions.
Interaction with other medicinal products
Broad-spectrum antibiotics reduce primobolan depot cycle the laxative effect; diuretics and corticosteroids increase the risk of water and electrolyte imbalance; possible increased sensitivity to cardiac glycosides.
Do not use without medical supervision primobolan depot cycle for more than 10 days. In the application of the sodium picosulfate in high doses and for a long time can be symptoms appear water-electrolyte imbalance, including hyponatremia. We can not exclude the possibility of spontaneous bowel movements. If the character of stool while taking sodium picosulphate does not change for a long time, you should consult a doctor to determine the cause of constipation.
Effects on ability to drive vehicles and work primobolan depot cycle with the technique of
Sodium picosulphate not affect the ability to motor vehicles and other equipment management.